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Far Infrared Therapy Inhibits Vascular Endothelial Inflammation via the Induction of Heme Oxygenase-1

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Objective— Survival of arteriovenous fistulas (AVFs) in hemodialysis patients is associated with both far infrared (FIR) therapy and length polymorphisms of the heme oxygenase-1 (HO-1) promoter. In this study, we evaluated whether there is an interaction between FIR radiation and HO-1 in regulating vascular inflammation.

Methods and Results— Treatment of cultured human umbilical vein endothelial cells (ECs) with FIR radiation stimulated HO-1 protein, mRNA, and promoter activity. HO-1 induction was dependent on the activation of the antioxidant responsive element/NF-E2-related factor-2 complex, and was likely a consequence of heat stress. FIR radiation also inhibited tumor necrosis factor (TNF)-α–mediated expression of E-selectin, vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, monocyte chemoattractant protein-1, interleukin-8, and the cytokine-mediated adhesion of monocytes to ECs. The antiinflammatory action of FIR was mimicked by bilirubin, and was reversed by the HO inhibitor, tin protoporphyrin-IX, or by the selective knockdown of HO-1. Finally, the antiinflammatory effect of FIR was also observed in patients undergoing hemodialysis.

Conclusions— These results demonstrate that FIR therapy exerts a potent antiinflammatory effect via the induction of HO-1. The ability of FIR therapy to inhibit inflammation may play a critical role in preserving blood flow and patency of AVFs in hemodialysis patients.

Far infrared (FIR) therapy improves survival of arteriovenous fistulas in hemodialysis patients, but the underlying mechanism is unknown. We now report that FIR radiation stimulates heme oxygenase-1 (HO-1) expression in endothelial cell and that the induction of HO-1 confers antiinflammatory actions that may underlie the beneficial effects of FIR therapy.
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Carmen Tomescu Vancouver, BC
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M. Arnold, MN.
I am writing this letter of testimony, to share what the Bio-Mat has done for me. Using the Bio-Mat helped to decrease body aches and other ailments like sore throat and muscle pains. I am also able to relax and sleep better at night. By sharing the Bio-Mat with my friends, it eased their body aches and pains as well. The Bio-Mat is a helpful way to relieve body ailments and I give a thoughtful thank you.
Efigenia Ventura
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Miki & Dr. Steve Jarvie
“Until I first tried the Biomat in November 2005, I relied on physical therapy and analgesics to control the pain I endured from multiple injuries I suffered over 25 years as an ironworker. I was unable to move my head from side to side without turning my upper body. Every joint in my body ached. My sister had given me the Biomat and Alkal-Life water unit to use in September 2005, but I was skeptical. She finally convinced me to try the may for my pain for a week and report to her. Each day I seemed to be getting better. I started slow and easy as she recommended and at the end of the week I was doing an hour daily on the red setting. After a few days of this, I noticed that every injury I had suffered while working iron surfaced, then gradually disappeared. I also suffer from COPD and use oxygen tanks daily. After the first week, I decided to hook up the Alkal-Life water unit. I began with an 8.5 pH. Instantly, I felt my brain clear. I guess I was getting more oxygen. I have been using the Biomat a few times a week and drinking alkaline water daily. I am now pain free ( I no longer need physical therapy and analgesics ). I have more energy. I still require oxygen occasionally when I overexert myself. I used to feel “disabled” and useless. My life is now fuller than I imagined it could ever be at my age. The Biomat and Alkal-Life Water System have greatly improved my life.”
T. Traversie of Ridgeview, SD
“I first experienced the biomat at a health expo. After 10 minutes of laying on it I was amazed that it took away my hip and knee pain that I’d been unable to find relief from after several different treatments including chiropractic and physical therapy. As a pharmacist I was really impressed that it worked so much better than anything my traditional background had led me to. My experience stuck with me so when we opened a holistic skincare and cosmetics spa, I insisted we include the biomat. Since using the biomat regularly in conjunction with drinking alkaline ionized water, I have been pleasantly surprised at the improvement. I am so happy how much better I feel and how much more energy I now have. I look forward to sharing it with as many people as I can.”
Cynthia Cisneros, RPh
"Far infrared ray emitting Biomat increases blood circulation and oxygen supply to damaged tissues (aiding reduction of joint and muscle pain or sports injuries), promotes relaxation and comfort, induces sleep and relieves as shown in this case study."
Dr. George Grant
Hey Jennifer, this is Debra Schamel with Reborn Organics and I just wanted to send you a statement that the Biomat is working out fantastic here at Reborn Organics. Our clients love the therapy and it has been Doctor verified that Reborn Organics healing sessions has and is reducing cancer cells. Thanks you so much for all your help in making our dreams come true.
Deborah Schamel
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Dr. Erika Fayina Marie, DACM
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Karol Barrow
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